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Authors
Affiliations
1 Ultra College of Pharmacy, Madurai, Tamil Nadu, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 544-546
Abstract
The present work deals with synthesis and evaluation of some novel phenylthiazole and quinazoline combination derivatives of biological interest. The reaction of acetophenone with thiourea formed 4-phenylthiazol-2-amine (I) was refluxed with N-chloroacetyl anthranillic acid (II) in the presence of K2CO3 in dry ethanol under anhydrous condition yields 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]-quinazolin-4(3H)one(III). The 2-chloromethyl-3-[4-(phenyl) thiazol-2-yl] quinazolin-4(3H)–one(III) and respective aromatic amines was refluxed in dry pyridine and acetic anhydride formed N-3-[4-(4–phenyl) thiazol–2–yl]-[2-(substituted amino) methyl] quinazoline-4 (3H)-one derivatives (IV).The synthesized compounds are to be screened for antibacterial activity.
